I frequently get e-mails from people that have been at my talks about the theme I use in Visual Studio. Instead of continuing to reply individually, I've decided to point them to this blog post from now on. As a long-time Delphi user I've been used to the dark background (Twilight is it's name in Delphi) and find it much easier on the eyes. In Visual Studio I'm using a variation of Rob Conery's theme which in itself is a variation of Jon Lam's theme.
My font is "BitStream Vera Sans Mono" size 11. You can download the theme from here